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GRK2243 Symposium

Understanding Ubiquitylation:

From Molecular Mechanisms to Disease

2-4 June 2025 I Würzburg, Germany 

The Meeting

The Meeting

The post-translational modification of proteins with ubiquitin ("ubiquitylation") has taken center stage in eukaryotic cell biology. Ubiquitylation mediates the degradation of regulatory and damaged proteins, protein aggregates and even entire organelles. Moreover, it controls a wide variety of non-proteolytic processes such as DNA damage repair, receptor signaling and endocytosis.

 

Given the multi-faceted cellular functions of protein ubiquitylation, it is not surprising that abnormalities of the ubiquitin system lead to various human diseases including cancer, neurodegenerative disorders and infectious diseases. Moreover, the ubiquitin system has emerged as a promising target for therapeutic intervention, and drugs interfering with ubiquitin-mediated proteolysis are successfully used for the treatment of certain cancers. 

 

This Symposium aims to showcase the most recent, exciting progress towards understanding molecular mechanisms, cellular functions and pathogenic aberrations of the ubiquitin system as well as developing novel therapeutic strategies targeting it. The meeting will feature cutting-edge research presentations by international leaders in the field, additional short talks selected from submitted abstracts, and a large poster session along with poster teasers. There will be ample opportunity for scientific interactions between all participants to stimulate further progress in ubiquitin research.

GRK2243

The Symposium is organized by the Research Training Group GRK2243, a ubiquitin-themed graduate program, which has been funded by the German Research Foundation DFG since April 2017. The GRK2243 offers cutting-edge research projects and a structured, interdisciplinary training program for more than 20 PhD students and postdocs at the University of Würzburg.

For further information, please visit our webpage: 

www.uni-wuerzburg.de/grk2243

REGISTRATION DEADLINE

1 March 2025

ABSTRACT SUBMISSION

DEADLINE

15 April 2025

Short talks will be selected from abstracts.

       

            Find us on Bluesky

                @GRK2243

                #wUeBI2025

Registration closed
Speakers

Program

Day 1 - 2 June 2025

12.30 - 2.00 pm     Arrival and registration

           2.00 pm      Welcome address

 2.10 - 4.00 pm      Session 1: Proteostasis

                           The EMBO Keynote Lecture: Tom Rapoport

Mechanism of ER-associated protein degradation

                           Michael Rape - Proteolytic control of gene expression in development and disease

                               Mark Hipp - VCP as a ubiquitin-dependent disaggregase

                               Paul Müller - p97/VCP is required for piecemeal autophagy of aggresomes

 4.00 - 4.30 pm      Coffee break

 4.30 - 6.15 pm      Session 1 (ctd.): Proteostasis

                           Anja Bremm - Ubiquitin-dependent regulation of selective autophagy

                           Florian Wilfling - Ultrastructural visualization of macroautophagy

                           Jan Keiten-Schmitz - Induced proximity to PML protects TDP-43 from aggregation via                                                                         SUMO-ubiquitin networks 

                           Thomas Mercer - Ubiquitin Phosphoserine 65 is a Novel Epigenetic Mark Implicated in                                                                  Parkinson's Disease

                               Katrin Trunk - The USP11/TCEAL1 complex promotes transcription elongation to                                                                     sustain oncogenic gene expression in neuroblastoma

 6.15 - 6.45 pm      Poster power show I (1 min teaser presentations)

 7.00 - 9.00 pm      Poster session I (odd numbers)

                           & Finger food dinner

Day 2 - 3 June 2025

 9.00 - 10.50 am   Session 2: Structural biology and Enzymology

                          Keynote Lecture: Brenda Schulman

Structural mechanisms of regulation by the ubiquitin                                           proteasome system

                           Katrin Rittinger - TRIM family proteins – more than just your typical E3 ligase

                           Sonja Lorenz - Illuminating HECT E3 regulation and substrate recognition  

                               Jessica Huber - Structural mechanism of the small HECT ligase HECTD3

10.50 - 11.20 am   Coffee break

11.20 - 12.45pm   Session 2 (ctd.): Structural biology and Enzymology

                           Tim Clausen - The ubiquitin big bang theory

                           Paul Elliott - Understanding specificity within ubiquitin/FAT10 conjugation                                                                      pathways  

                           Leo Kiss - Deciphering the ubiquitin degradation code

                               Sascha Amann - Structural basis of ubiquitin chain recognition by the human 26S                                                                  proteasome

 12.45 - 2.15 pm    Lunch | Meet the editor (Hartmut Vodermaier, EMBO Press)

 2.15 - 4.00 pm     Session 2 (ctd.): Structural biology and Enzymology

                           Helen Walden - Targeting Parkin substrates

                           Anne Schütz - Diverse spectrum of molecular defects in pathogenic mutants 

                                                         of VCP/p97

                           Georg Winter - Identification and mechanistic characterization of small-molecule                                                                  degraders 

                           Zijuan Wang - UFMylation regulates DNA damage repair by promoting NHEJ                                                                   complex engagement on chromatin

                               Devanshi Gupta - Neddylation: a new modification for dynein-mediated transport                                                                  in cells 

      

 4.00 - 4.30 pm      Coffee break

 4.30 - 5.00 pm      Poster Power Show II (1 min teaser presentations)

 5.00 - 7.00 pm      Poster session II (even numbers)

 8.00 pm                Conference dinner at restaurant Backöfele                          

Day 3 - 4 June 2025

 9.00 - 10.45 am    Session 3: Tool and drug development

                           Sara Buhrlage - A novel chemical biology platform for deubiquitylases

                           Philipp Schenk - Targeting USP9X: Cancer Cell Responses to Smal Molecule                                                                         Inhibition

                           Heeseon An - Comparative degradomics identifies impaired protein degradation

                                                        in cancer

                               Nicola Berner - Chemical proteomics meets molecular degraders - elucidating the                                                            target selectivity of kinase inhibitor based PROTACs

                           Gerbrand v. d. Heden v. Noort - Ubiquitination and ADP-ribosylation: post-

                                                                                         translational crosstalk

10.45 - 11.15 am   Coffee break

11.15 - 1.00 pm     Session 4: Infection and Immunity

    Jonathan Pruneda - Pathogenic bacteria make surgical strikes on host ubiquitin

                                                                   signaling

                           Lillie Bell - Targeting and ubiquitination of bacterial pathogens by the cell                                                                  defence factor RNF213 

                           Tyler Rhinesmith - TRIM21 induces selective autophagy of viruses and bacteria

                               Andrea Ablasser - Sensing DNA as a danger signal through the cGAS-STING                                                                          pathway

                           

 12.45 pm              Award ceremony & Closing remarks

                           Lunch (packed)

                               Departure

Program

Registration & Fees

REGISTRATION DEADLINE

1 March 2025

ABSTRACT SUBMISSON DEADLINE

15 April 2025

Registration fees

PhD student, Postdoc                      150 €

Academic, Industry.                            250 €

Registration closed

Registration includes:

  • Conference materials

  • Access to all sessions

  • Conference dinner at restaurant Backöfele

  • Food and drinks during coffee breaks, lunches and finger food during poster session

 

Accommodation is not included. Please see hotel registration information under LOCATION below.

Payment

Please note that payment must be submitted only after receipt of confirmation that your registration has been accepted. At that point, you will receive an email from the organizers with detailed payment instructions. Payment ought to be made via national and international bank transfer exclusively. Credit card payment is not possible.

 

Cancellation and registration fee refund policy:

  1. Notification of cancellation should be made in writing and sent to the conference organizers: 
    ubiquitin2025@uni-wuerzburg.de

     

  2. 100% refund (less 25 € handling fee) if a notification e-mail reaches the organizers on or before
    15 April 2025.

     

  3. No refund on cancellations after 15 April 2025.

Selection criteria

The admission of participants (in case of overbooking) will be guided by the submitted abstracts, according to the expected scientific impact of the work on the conference and the field. It is thus recommended that all participants submit an abstract at the time of registration and specify whether they wish to present a poster or short talk.

Abstract guidelines

 

Please download the abstract template and follow the instructions therein. 

To submit your abstract please sent the wordfile via email to 

ubiquitin2025@uni-wuerzburg.de

Poster specifications

 

Please bring one printed copy of your poster in portrait orientation (not landscape). 

POSTERS SHOULD HAVE A SIZE OF DIN A0 (84,1 x 118,9 cm).

Short talks

 

A number of short talks (10 min talk followed by 5 min discussion) – preferentially by early-career scientists – will be selected from the submitted abstracts ahead of the meeting.

Please indicate whether you would like to be considered for a short talk at the time of registration. Applicants will be notified at least three weeks before the meeting.

Registration & Fees
Contact

Coordinator GRK2243: Julia Seubert 

Email: ubiquitin2025@uni-wuerzburg.de

Contact

Organizing committee

Andreas Brunschweiger

Pharmaceutical and Medicinal Chemistry, University of Würzburg

Alexander Buchberger

Biocenter, University of Würzburg

Martin Eilers

Biocenter, University of Würzburg

Caroline Kisker

Rudolf Virchow Center, University of Würzburg

Hermann Schindelin

Rudolf Virchow Center, University of Würzburg

Christoph Sotriffer

Pharmaceutical and Medicinal Chemistry​, University of Würzburg

Amel Aziba 

Biocenter, University of Würzburg

Sebastian Bothe 

Rudolf Virchow Center, University of Würzburg

Shaliya Puthanveedu Hashardeen

Rudolf Virchow Center, University of Würzburg

Lamiya Mahmudova

Biocenter, University of Würzburg

Paul Müller 

Biocenter, University of Würzburg

Jonathan Patzke 

Rudolf Virchow Center, University of Würzburg

Location

Meeting Venue

Congress Center Würzburg

Pleichertorstraße

97070 Würzburg

Germany

For further information, please check:

www.wuerzburg.de/tourismus/tagungen-kongresse/tagung/besucher/index.html

(German website only)

441301_congress_centrum_aussen.jpg

City of Würzburg

Arrival and parking at the Congress Centrum

By car: Please enter the destination "Pleichertorstraße" in the navigation system. There are several parking lots in the immediate vicinity of the Congress Centrum: (I) the Congress Centrum underground parking at Pleichertorstraße (246 slots), (II) Congress Centrum parking lot at the Kranenkai (60 slots), and (III) Talavera parking lot (1000 free parking spaces on the other side of the river Main, 5-minute walk from the Congress Centrum).

 

By public transport: From the main train station, you can reach the Congress Centrum by tramway line 2 to "Zellerau", stop "Congress Centrum".

 

By foot: From the main train station walk towards the river Main and either follow the street "Röntgenring" or walk through the Ringpark, about 10 minutes walk.

Accommodation

Please note that accommodation is not included in the registration fee and has to be organized by the participants on their own.

For the two nights, June 2 - 4, 2025, participants are offered rooms at the Maritim Hotel (incl. breakfast) which is directly located at the Congress Center: single room comfort for 156 €/per night and double room comfort for 177 €/per night. Please make your reservation directly with the hotel, using code "GRK2243". A limited number of rooms have been reserved for the conference and will be available on a first-come-first-serve basis until April 21, 2025.

 

For budget hotels, we recommend Ibis or B&B Hotel in Veitshöchheimer Straße, which are in walking distance to the conference venue.

 

For further accommodation opportunities, please check here:

www.wuerzburg.de/tourismus/unterkunft-buchen/hotels-pensionen/index.html

About Würzburg

For further information, please check the official tourist information website of Würzburg:

www.wuerzburg.de/en/visitors/index.html

Copyright: Peter Schumann (cover image, www.dasistwuerzburg.de), Congress-Tourismus-Würzburg & Katrin Heyer

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